EFFECT OF ORAL GnRH ANTAGONIST RELUGOLIX ON BLOOD HORMONE AND OOCYTE RETRIEVAL - A STUDY OF THE METHOD OF RELUGOLIX ADMINISTRATION

To compare the blood hormone levels, number of oocytes retrieved, and culture results cycles those using relugolix with adopting more conventional method cetrorelix. From December 2010 to February 2021, 251 [214 in cetrorelix (C) group 37 (R) group] ovarian stimulation GnRH antagonists were included study. Using E2 level per oocyte retrieval C (257 pg/ml) as a standard, R was divided into groups below standard (RB group) above (RA group), compared. agonist used trigger. There no significant differences age, AMH, total HMG/FSH doses among C, RB, RA groups. Hormone levels 2 days before retrieved significantly higher for P4 (1.0±0.5, 0.5±0.2, 0.4±0.2 ng/ml), LH. The (14.1±7.4, 12.7±6.2, 4.2±3.8) lower group, but there difference percentage mature oocytes. Premature ovulation observed one case each fertilization rate, cleavage or good blastocyst rate cut-off value calculated from RB groups, which 0.37. Applying this we compared 0.37 As result, (4.7±4.9, 10.2±6.6) It suggested that oral antagonist did not affect results. On other hand, it low may result retrieved.